Objective: The efficiency of single dose methotrexate treatment applied on patients with ectopic pregnancy is researched. Materials and method: 30 patients in between ages of 21 and 40 who have received single dose MTX treatment due to ectopic pregnancy is included in the study. All the patients were stabile as hemodynamically. The serum B-hCG levels, USG findings prior to the MTX treatment are recorded. Serum B-hCG levels are monitored in accordance with the single dose MTX protocol. Results: The average age of the 30 cases taken in the study is 30.63±4.36. The B-hCG levels of the cases as changing in between 160 and 10910, their average is 2386.80±2498.68. The MTX doses they use as changing in between 50 mg and 100 mg, its average is 67.67±13.50. While 18 (60%) of the cases had no previous surgical history. While the mass size of 6 (20%) of the cases is below 4 cm, in 24 (80%) of cases it is between 5 cm and 5.5 cm. 4 (13.3%) of the cases is receiving additional dose of MTX. Laparotomy is applied on 3 (10%) of the cases due to tubal rupture developing during the treatment. Conclusion: The medical treatment to be applied on nonruptured ectopic pregnancies has many advantages. Less tubal damage occurs by the medical treatment, it decreases the morbidity for anesthesia and surgery.