Effect of resveratrol in experimental osteoarthritis in rabbits


ELMALI N., ESENKAYA İ. , HARMA A., ERTEM K., Turkoz Y., Mizrak B.

INFLAMMATION RESEARCH, cilt.54, ss.158-162, 2005 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 54 Konu: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s00011-004-1341-6
  • Dergi Adı: INFLAMMATION RESEARCH
  • Sayfa Sayısı: ss.158-162

Özet

Objective: Resveratrol (trans-3,4',5-trihydroxystilbene) is a phytoalexin found in high concentration in the skins of grapes and red wines which has been shown to have antiinflammatory, anticancerogen and antioxidant properties. Resveratrol is a potent and specific inhibitor of nuclear factor kappa B ( NF-kappa B). Resveratrol also inhibits COX-2 gene expression and enzyme activity. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental osteoarthritis (OA) model in rabbits.