Effect of resveratrol in experimental osteoarthritis in rabbits

ELMALI N., ESENKAYA İ., HARMA A., ERTEM K., Turkoz Y., Mizrak B.

INFLAMMATION RESEARCH, vol.54, no.4, pp.158-162, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1007/s00011-004-1341-6
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.158-162


Objective: Resveratrol (trans-3,4',5-trihydroxystilbene) is a phytoalexin found in high concentration in the skins of grapes and red wines which has been shown to have antiinflammatory, anticancerogen and antioxidant properties. Resveratrol is a potent and specific inhibitor of nuclear factor kappa B ( NF-kappa B). Resveratrol also inhibits COX-2 gene expression and enzyme activity. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental osteoarthritis (OA) model in rabbits.