Similar prevalence of somatic TSH receptor and Gs alpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey


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GOZU H. I. , BIRCAN R., KROHN K., MUELLER S., VURAL S., GEZEN C., et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY, cilt.155, ss.535-545, 2006 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 155 Konu: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1530/eje.1.02253
  • Dergi Adı: EUROPEAN JOURNAL OF ENDOCRINOLOGY
  • Sayfa Sayısı: ss.535-545

Özet

Objective: Differences in iodine intake could account for the variable prevalences reported for somatic TSH receptor (TSHR) mutations in toxic thyroid nodules (TTNs). However, this question has not been settled, since no study has yet determined the TSHR mutation prevalence in regions with different iodine supplies in the same population using the same methodology. Therefore, we studied the prevalence of somatic TSHR mutations in TTNs from patients living in iodine-deficient or -sufficient regions in Turkey.