Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats


FİDAN H., ŞAHİN Ö., YAVUZ Y., KİLBAS A., ÇETİNKAYA Z., ELA Y., et al.

CRITICAL CARE MEDICINE, cilt.35, ss.2822-2829, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Objective: Sepsis and ensuing multiorgan failure continue to be the major causes of mortality in intensive care units. Nuclear factor (NF)-kappa B activation is supposed to be one of the targets in the treatment of sepsis. We studied the effectiveness of caffeic phenethyl ester (CAPE), a known NF-kappa B inhibitor, in cecal ligation and puncture (CLP)-induced sepsis and lung injury.