Jaundice and hepatic enzyme induction during lamotrigine therapy in a bipolar II patient


Selek S., Savaş H. A. , Savaş E., Herken H., Tutkun H., Gergerlioğlu H. S.

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, vol.9, no.1, pp.65-67, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1080/13651500510014774
  • Title of Journal : INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
  • Page Numbers: pp.65-67

Abstract

Lamotrigine is a novel mood stabiliser as well as an anti-epileptic drug that has already been used for the prevention of convulsions. Despite several known side effects, hepatic dysfunction related to the drug has not been widely reported. A few cases have been observed in neurological, especially paediatric patients, but not in psychiatric patients. We report a case of cholestatis which occurred 6 weeks after starting lamotrigine therapy and which resolved after discontinuation, during the acute phase of disease. To the best of our knowledge, this is the first case of lamotrigine associated with cholestasis reported in patients with bipolar disorder.