Effects of trapidil on renal ischemia-reperfusion injury


AVLAN D., TAMER L., AYAZ L., POLAT A., OZTURK C., OZTURHAN H., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.41, no.10, pp.1686-1693, 2006 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 10
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jpedsurg.2006.05.064
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1686-1693
  • Keywords: ischemia-reperfusion injury, kidney, oxidative stress, peroxynitrite, trapidil, TNF-alpha, 3-nitrotyrosine, NITRIC-OXIDE, POLY(ADP-RIBOSE) SYNTHETASE, INHIBITION, ACTIVATION

Abstract

There is increasing evidence to suggest that reactive oxygen and nitrogen species play a role in the pathogenesis of renal ischemia-reperfusion (I/R) injury. This study was designed to determine the possible protective effects of trapidil treatment against oxidative and nitrosative tissue injury of kidney induced by I/R.