Aim: The objective of the present study was to explore associations between obesity and musculoskeletal pain, quality of life (QoL), depression and physical activity level among children. Material and Method: The study enrolled 40 children diagnosed with obesity at endocrinology outpatient clinics and a control group of healthy children with normal body mass index. Presence of musculoskeletal pain was questioned. Children allocated in both groups were administered the Quality of Life Scale for Children, the Depression Scale for Children and the International Physical Activity Questionnaire-Short Form.Results: There was no difference between obese children and control group with respect to mean age and sex distribution. Obese children were found to have a higher frequency of musculoskeletal pain compared to control group (p < 0.01). Scores for physical function and psychosocial health domains of the QoL scale were significantly low among obese children (p < 0.001 and p < 0.01, respectively). Study groups did not show differences in emotional function domain of the QoL scale and depression scale. Although both groups were similar with regard to physical activity level, obese children were found to spend significantly longer time sitting during the day (p <0.001). Discussion: In children, obesity is associated with an increased frequency of musculoskeletal pain as well as impaired QoL. While designing pediatric obesity treatment programs, consideration should be given to the presence of pain in those children.