How yeast re-programmes its transcriptional profile in response to different nutrient impulses


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Dikicioglu D., Karabekmez E. , Rash B., Pir P., Kirdar B., Oliver S. G.

BMC SYSTEMS BIOLOGY, cilt.5, 2011 (SCI İndekslerine Giren Dergi)

Özet

Background: A microorganism is able to adapt to changes in its physicochemical or nutritional environment and this is crucial for its survival. The yeast, Saccharomyces cerevisiae, has developed mechanisms to respond to such environmental changes in a rapid and effective manner; such responses may demand a widespread reprogramming of gene activity. The dynamics of the re-organization of the cellular activities of S. cerevisiae in response to the sudden and transient removal of either carbon or nitrogen limitation has been studied by following both the short-and long-term changes in yeast's transcriptomic profiles.