Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension


Collak F. , DEMİR Ü. , Özkanlı S. Ş. , Kurum E., ZERK P. E.

CANCER BIOLOGY & MEDICINE, cilt.14, ss.405-413, 2017 (SCI İndekslerine Giren Dergi)

Özet

Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p) YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in clinical samples of PCa and cell lines.