Exposure to hypertonic solutions during pregnancy induces autism-like behaviors via the NFAT-5 pathway in offspring in a rat model


Senkal E., Bagcioglu E., Eryigit U., Erbas O., Solmaz V.

PHYSIOLOGY & BEHAVIOR, vol.240, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 240
  • Publication Date: 2021
  • Doi Number: 10.1016/j.physbeh.2021.113545
  • Title of Journal : PHYSIOLOGY & BEHAVIOR
  • Keywords: Autism, Pregnant rat model, Hyperosmolar state, NFAT5 pathway, MATERNAL IMMUNE ACTIVATION, SPECTRUM DISORDERS, PRENATAL EXPOSURE, TH17 CELLS, INTERLEUKIN-17A, MACROPHAGES, CHILDREN, BRAIN, IL-17, RISK

Abstract

Objectives: to investigate the effects of hyperosmolar state (HS) on immune response and inflammation via the NFAT5 pathway and examine whether immune-mediated conditions trigger autism-like behavior in offspring.