The Effects of Oxytocin on Cognitive Defect Caused by Chronic Restraint Stress Applied to Adolescent Rats and on Hippocampal VEGF and BDNF Levels

Dayi A., Cetin F. , Sisman A. R. , Aksu I., Tas A., Gonenc S., ...More

MEDICAL SCIENCE MONITOR, vol.21, pp.69-75, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2015
  • Doi Number: 10.12659/msm.893159
  • Title of Journal : MEDICAL SCIENCE MONITOR
  • Page Numbers: pp.69-75


Background: Because brain development continues during adolescence, the effects of chronic stress on hippocampal changes that occur during that period are permanent. Oxytocin, which is synthesized in the hypothalamus and has many receptors in brain regions, including the hippocampus, may affect learning-memory. This study aimed to investigate chronic restraint stress on hippocampal functions, and hippocampal vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) levels in adolescent male and female rats and the role of oxytocin in these effects.