Do young women with polycystic ovary syndrome show early evidence of preclinical coronary artery disease?


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Topcu S., ÇALIŞKAN M. , Özçimen E. E. , Tok D., Uçkuyu A., Erdogan D., ...More

HUMAN REPRODUCTION, vol.21, no.4, pp.930-935, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2006
  • Doi Number: 10.1093/humrep/dei431
  • Title of Journal : HUMAN REPRODUCTION
  • Page Numbers: pp.930-935
  • Keywords: coronary artery disease, coronary flow reserve, polycystic ovary syndrome, 2ND-HARMONIC ECHO-DOPPLER, FLOW RESERVE ASSESSMENT, LEFT-VENTRICULAR MASS, INSULIN-RESISTANCE, MICROVASCULAR DYSFUNCTION, DIASTOLIC DYSFUNCTION, CARDIOVASCULAR RISK, BLOOD-PRESSURE, PREVALENCE, PREDICTORS

Abstract

BACKGROUND: It is thought that women with polycystic ovary syndrome (PCOS) are at increased risk of developing cardiovascular diseases. METHODS: In this study, we used transthoracic echocardiography to measure coronary flow reserve (CFR) in 28 women with PCOS and in 26 healthy women. RESULTS: The PCOS and the control groups were similar in terms of age (27.1 +/- 4.5 versus 28.8 +/- 4.4 years) and BMI (26.6 +/- 5.7 versus 24.7 +/- 4.4 kg/m(2)). Fasting insulin levels and homeostasis model assessment insulin resistance index were higher in the PCOS group. LH, the LH/FSH ratio, total testosterone, free testosterone and androstenedione were higher in the PCOS group. FSH, estradiol, prolactin, progesterone, cholesterol, triglyceride and high-sensitive C-reactive protein were similar between the two groups, but homocysteine levels were higher in the PCOS group. Baseline diastolic peak f low velocity (DPFV) (25.0 +/- 4.6 versus 23.3 +/- 2.7 cm/s, P > 0.05), hyperaemic DPFV (71.2 +/- 12.8 versus 73.0 +/- 12.9 cm/s, P > 0.05) and CFR (2.8 +/- 0.8 versus 3.2 +/- 0.8 cm/s, P > 0.05) of the left anterior descending coronary artery were similar between the two groups. CONCLUSION: We conclude that in young women with PCOS and without cardiovascular risk factors, CFR is preserved.