Biochemical alterations in neonatal hypoxic ischaemic brain damage


GUCUYENER K., GUR T., OZ E., TURKYILMAZ C., Ozturk G. , ERBAS D., ...More

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol.57, no.6, pp.567-570, 1997 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 6
  • Publication Date: 1997
  • Doi Number: 10.1016/s0952-3278(97)90562-7
  • Title of Journal : PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
  • Page Numbers: pp.567-570

Abstract

Asphyxiated (n = 39) and control (n = 23) were elected for the study. Free radical-mediated lipid peroxidation, prostaglandin E-2 and vitamin E levels were studied and the degree of hypoxic ischaemic encephalopathy was determined in each case. In the hypoxic group the concentration of prostaglandin E-2 activity (P < 0.05) and malondialdehyde levels (P < 0.01) were significantly higher when compared to that of controls. The high vitamin E concentrations in the asphyxiated infants supports the role of oxygen free radicals in hypoxic ischaemic encephalopathy of newborns.