Is serum Klotho protective against atherosclerosis in patients with type 1 diabetes mellitus?


Keles N., Doğan B. , Kalçık M., ÇALIŞKAN M. , Keles N. N. , Aksu F., et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS, cilt.30, ss.126-132, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 30 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jdiacomp.2015.09.013
  • Dergi Adı: JOURNAL OF DIABETES AND ITS COMPLICATIONS
  • Sayfa Sayısı: ss.126-132

Özet

Objective: Klotho deficiency is associated with several metabolic disorders. Two dimensional (2D) longitudinal strain (IS) of left ventricle (LV), carotid artery intima-media thickness (CIMT), flow-mediated dilation (FMD) of brachial artery and epicardial fat thickness (EFT) have been reported to be early predictors of atherosclerosis. We aimed to investigate the relationship between serum Klotho levels and these early predictors of atherosclerosis in patients with type 1 diabetes mellitus (DM).