Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma


Abignano G., Aydin S. Z. , Castillo-Gallego C., Liakouli V., Woods D., Meekings A., et al.

ANNALS OF THE RHEUMATIC DISEASES, cilt.72, ss.1845-1851, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 72 Konu: 11
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1136/annrheumdis-2012-202682
  • Dergi Adı: ANNALS OF THE RHEUMATIC DISEASES
  • Sayfa Sayısı: ss.1845-1851

Özet

Background Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4m resolution, comparable with microscopy (virtual biopsy'). The present study evaluated OCT to detect and quantify skin fibrosis in SSc.