ANNALS OF THE RHEUMATIC DISEASES, vol.72, no.11, pp.1845-1851, 2013 (Peer-Reviewed Journal)
Background Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4m resolution, comparable with microscopy (virtual biopsy'). The present study evaluated OCT to detect and quantify skin fibrosis in SSc.