Benign Bone Cyst Mimicking Bone Metastasis Demonstrated on Ga-68-FAPI

GÜNGÖR S., Selcuk N. A.

CLINICAL NUCLEAR MEDICINE, vol.47, no.1, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 47 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1097/rlu.0000000000003796
  • Journal Indexes: Science Citation Index Expanded, Scopus, EMBASE, MEDLINE
  • Keywords: bone cyst, bone metastasis, Ga-68-FAPI, PET/CT, F-18-FDG PET/CT, ACTIVATION PROTEIN, FAPI UPTAKE, PATIENT, CANCER


A 59-year-old woman with lobular breast cancer was referred to nuclear medicine department for a Ga-68-FAPI PET/CT study after completion of treatment to rule out the possibility of metastatic disease. It revealed a lytic lesion showing increased FAPI accumulation in the right acetabulum, highly suspicious for bone metastasis. In comparison to an initial F-18-FDG PET/CT study done 2 years before, the lytic lesion showing no FDG uptake in the right acetabulum remained unchanged, and the findings were consistent with bone cyst. This case highlighted that benign bone cyst may demonstrate increased Ga-68-FAPI uptake mimicking bone metastasis on Ga-68-FAPI PET/CT.