Efficacy of alfuzosin and sildenafil combination in male patients with lower urinary tract symptoms


Öztürk M. İ. , Kalkan S., Koca O., Gunes M., Akyüz M., KARAMAN M. İ.

ANDROLOGIA, cilt.44, ss.791-795, 2012 (SCI İndekslerine Giren Dergi)

Özet

Lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are frequently encountered in ageing males. We compared the efficacy of alfuzosin 10mg alone or in combination with sildenafil 50mg in the treatment of LUTS due to benign prostatic hyperplasia. One hundred male patients older than 45years were randomized to two groups containing 50 patients each; one group receiving alfuzosin 10mg and the other group alfuzosin 10mg combined with sildenafil 50mg. International Prostate Symptom Score (IPSS), quality of life (QoL), maximum flow rate (Qmax), prostate volume and post-void residual urine were evaluated. The mean age was 60.2 +/- 17.8. Mean data of evaluated parameters in both groups at the end of 3rd month compared with baseline values are given respective order as; 5.1 (26.8%) and 5.8 (28.2%) points decreases in IPSS; 1.6 (41.1%) and 1.8 (45%) points decreases in QoL; and 3.4 (29.6%) and 3.4 (33%) points increases in Qmax. The outcomes of our study cannot be interpreted in such a way to report that alpha blocker-PDE5 inhibitor combination has a better efficacy than alpha blocker treatment alone in patients with LUTS.