Methylene Tetrahydrofolate Reductase Deficiency: the Hidden Risk in Paediatric Anaesthesia


ORHON Z. N. , KOLTKA E. N. , TUFEKCI S., BULDAG C., KISA A., Durakbasa C. U. , ...More

TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION, vol.45, no.5, pp.277-281, 2017 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.5152/tjar.2017.68366
  • Title of Journal : TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
  • Page Numbers: pp.277-281

Abstract

Objective: Methylene tetrahydrofolate reductase (MTHFR) deficiency is an autosomal recessive disorder that results in increased homocysteine levels in the body. Hyperhomocysteinemia causes a predisposition to venous and arterial thrombosis and ischaemic insults. The incidence of the deficiency is around 40% in some countries. In this study, we aimed to evaluate the effects of anaesthetic agents in children with MTHFR deficiency.