Methylene Tetrahydrofolate Reductase Deficiency: the Hidden Risk in Paediatric Anaesthesia


ORHON Z. N. , KOLTKA E. N. , TUFEKCI S., BULDAG C., KISA A., Durakbasa C. U. , et al.

TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION, cilt.45, ss.277-281, 2017 (ESCI İndekslerine Giren Dergi)

  • Cilt numarası: 45 Konu: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/tjar.2017.68366
  • Dergi Adı: TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
  • Sayfa Sayısı: ss.277-281

Özet

Objective: Methylene tetrahydrofolate reductase (MTHFR) deficiency is an autosomal recessive disorder that results in increased homocysteine levels in the body. Hyperhomocysteinemia causes a predisposition to venous and arterial thrombosis and ischaemic insults. The incidence of the deficiency is around 40% in some countries. In this study, we aimed to evaluate the effects of anaesthetic agents in children with MTHFR deficiency.