Interaction among 5,10 methylenetetrahydrofolate reductase, plasminogen activator inhibitor and endothelial nitric oxide synthase gene polymorphisms predicts the severity of coronary artery disease in Turkish patients


Agirbasli D., Agirbasli M. A. , Williams S. M. , Phillips J. A.

CORONARY ARTERY DISEASE, cilt.17, ss.413-417, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 17 Konu: 5
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1097/00019501-200608000-00003
  • Dergi Adı: CORONARY ARTERY DISEASE
  • Sayfa Sayıları: ss.413-417

Özet

Background Genetic factors play a role in the onset of coronary artery disease. The objective of our study is to evaluate the single locus and combined effects of three different genetic polymorphisms (methylenetetrahydrofolate reductase C677T polymorphism, plasminogen activator inhibitor 4G/5G polymorphism, and endothelial nitric oxide synthase 3-27 base pairs repeat polymorphism) on the presence and extent of coronary artery disease in patients with early-onset coronary artery disease.