Low serum Insulin Like Growth Factor-1 in patients with Stress Urinary Incontinence

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Ozbek E., Otunctemur A., Sahin S., Ozcan L., Dursun M., Polat E., ...More

INTERNATIONAL BRAZ J UROL, vol.42, no.4, pp.787-792, 2016 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1590/s1677-5538.ibju.2015.0453
  • Title of Journal : INTERNATIONAL BRAZ J UROL
  • Page Numbers: pp.787-792


Objective: SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI.