Protective effect of trapidil against oxidative organ damage in burn injury

AVLAN D., TASKINLAR H., TAMER L., Camdeviren H. , OZTURHAN H., OZTURK C., ...Daha Fazla

BURNS, cilt.31, sa.7, ss.859-865, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Konu: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.burns.2005.04.013
  • Dergi Adı: BURNS
  • Sayfa Sayıları: ss.859-865


Animal models of thermal injury indicate reactive oxygen species and inflammatory cytokines as causative agents in tissue injury on various organs distant from the original wound. Trapidil has various properties, such as inhibition of platelet aggregation and lipid peroxidation as well as reduction of the inflammatory response to injury. This study was designed to determine the possible protective effect of trapidil treatment against oxidative organ damage in lung, intestine and kidney induced by cutaneous thermal injury.