5-hydroxytryptamine release in the anterior hypothalamic and the hippocampal areas of cholestatic rats

Terzioglu B. , Aypak C., Yananli H., Kucukibrahimoglu E., Yurdaydin M., Goren M.

LIFE SCIENCES, vol.78, no.10, pp.1078-1083, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 10
  • Publication Date: 2006
  • Doi Number: 10.1016/j.lfs.2005.06.025
  • Title of Journal : LIFE SCIENCES
  • Page Numbers: pp.1078-1083


Cholestasis contributes to the genesis of fatigue through several mechanisms. Among these mechanisms, affected serotonergic neurotransmission is important in the pathogenesis of central fatigue. Previously, elevated levels of 5-hydroxyindole acetic acid (5-HIAA), the metabolite of 5-hydroxytryptamine (5-HT) and increased 5-HT(2) receptor density were demonstrated in the anterior hypothalamus and in the hippocampus of bile duct resected rats (BDR), respectively. The aim of this paper is to demonstrate evoked 5-HT release in selected brain regions like anterior hypothalamus and hippocampal CA1 regions of cholestatic rats using BDR rats as an experimental model for cholestasis.