Tuberculous endocarditis (TBE) is a rare clinical entity, usually encountered during the course of miliary tuberculosis. Brain abscess is a very rare complication of TBE. Here, we report a case of valvular TBE presenting with meningoencephalitis due to septic embolization. The literature on well-documented cases of valvular TBE was also reviewed. Early diagnosis, an appropriate treatment strategy, surgical intervention, and close follow-up may lead to favorable outcomes in TBE. Surgical intervention (valve replacement and repair) may be required in 70% of TBE cases.