The effect of high dose losartan on erythropoietin resistance in patients undergoing haemodialysis

ODABAŞ A. R. , Cetinkaya R., Selcuk Y., Keles S.

PANMINERVA MEDICA, vol.45, no.1, pp.59-62, 2003 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2003
  • Title of Journal : PANMINERVA MEDICA
  • Page Numbers: pp.59-62


Aim. In some of the patients undergoing haemodialysis, (HD) resistance might develop against recombinant human erythropoietin (rHuEPO) used for treatment of anaemia. Recently, angiotensin-converting enzyme (ACE) inhibitors that are used to treat hypertension and congestive heart failure in HD patients have been suggested to contribute to anaemia as well by inhibiting erythropoiesis. Our purpose in this study is to investigate whether or not losartan, an angiotensin II (ATII) receptor antagonist, is causing rHuEPO resistance.