A brand-new cardiorenal syndrome in the COVID-19 setting

Apetrii M., Enache S., Siriopol D., Burlacu A., KANBAY A. , Kanbay M., ...More

CLINICAL KIDNEY JOURNAL, vol.13, no.3, pp.291-296, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.1093/ckj/sfaa082
  • Title of Journal : CLINICAL KIDNEY JOURNAL
  • Page Numbers: pp.291-296


Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient's lungs, recent data have documented that COVID-19 causes myocarditis, acute myocardial infarction, exacerbation of heart failure and acute kidney injury. Studies show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to its predecessor SARS-CoV, engages angiotensin-converting enzyme 2 (ACE2) as the entry receptor. ACE2 is also expressed in the heart, providing a link between coronaviruses and the cardiovascular system.