A brand-new cardiorenal syndrome in the COVID-19 setting


Apetrii M., Enache S., Siriopol D., Burlacu A., KANBAY A. , Kanbay M., ...Daha Fazla

CLINICAL KIDNEY JOURNAL, cilt.13, ss.291-296, 2020 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 13 Konu: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1093/ckj/sfaa082
  • Dergi Adı: CLINICAL KIDNEY JOURNAL
  • Sayfa Sayıları: ss.291-296

Özet

Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient's lungs, recent data have documented that COVID-19 causes myocarditis, acute myocardial infarction, exacerbation of heart failure and acute kidney injury. Studies show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to its predecessor SARS-CoV, engages angiotensin-converting enzyme 2 (ACE2) as the entry receptor. ACE2 is also expressed in the heart, providing a link between coronaviruses and the cardiovascular system.