Renal effects of long-term leptin infusion and preventive role of losartan treatment in rats

Gündüz Z., Dursun N., Akgün H., Öztürk F., Okur H., Koç N.

REGULATORY PEPTIDES, cilt.132, ss.59-66, 2005 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 132
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.regpep.2005.09.017
  • Sayfa Sayısı: ss.59-66


Background: Leptin has direct and indirect effects on renal pathophysiological characteristics. In the present study, the effects of long-term leptin infusion on the renal hemodynamics, renal excretory functions, and the expression of transforming growth factor-beta (TGF-beta), plasma endothelin-1 (ET-1) levels, and preventive effects of the angiotensin II type I receptor antagonist, losartan, on these renal changes were evaluated.