Colorectal carcinoma is one of the most frequently observed malignancy in the developed countries. Angiogenesis is essential for tumor growth and metastasis. The associations between peritumoral inflammatory cells and natural killer cells and angiogenesis to depth of invasion and lymph node metastasis were investigated in 75 colorectal adenocarcinoma specimens. There was not any statistically significant correlation between depth of invasion, lymph node metastasis and microvessel density, peritumoral macrophages, eosinophil leucocytes and naturel killer cells. There was a positive correlation between angiogenesis and peritumoral macrophages (p=0.021). Also natural killer cells and eosinophil leucocytes have a positive correlation (p=0.027). The relation between angiogenesis and eosinophil leucocytes and NK cells was insignificant. These data indicate that peritumoral inflammatory cells may contribute to tumor angiogenesis, and the sinergistic effect between peritumoral inflammatory cells.