MEDICAL HYPOTHESES, cilt.57, ss.238-240, 2001 (SCI İndekslerine Giren Dergi)
Recent articles about the roles and relationships of tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta I in various types of normal tissues and malignancies give rise to the question: 'Is there a relationship between them with regard to malignant melanoma progression?' In the light of many references, it seems to be highly probable that the tissue inhibitor of metalloproteinase-1, - being a multifunctional protein functions as a growth factor with possible stimulation by transforming growth factor-beta I in progression of malignant melanoma, rather than Its other existing functions in many different normal and cancer tissues (e.g. inhibition of the matrix metalloproteinases or functioning as an insignificant inhibitor of angiogenesis). (C) 2001 Harcourt Publishers Ltd.