TLR4 Asp299Gly and Thr399Ile and TLR2 intron 2 microsatellite gene polymorphism in patients with acute biliary pancreatitis: Does it cause the disease?


Anilir E., Ozen F., Ozemir I. A. , YILDIRIM İ. H. , Bilgic C., ALİMOĞLU O.

TURKISH JOURNAL OF SURGERY, cilt.34, ss.191-197, 2018 (ESCI İndekslerine Giren Dergi)

  • Cilt numarası: 34 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/turkjsurg.2017.3828
  • Dergi Adı: TURKISH JOURNAL OF SURGERY
  • Sayfa Sayısı: ss.191-197

Özet

Objectives: There has been coverage of Toll-like receptor 4 and Toll-like receptor 2 gene polymorphisms in inflammatory episodes in a number of studies. In view of the inflammatory nature of acute pancreatitis, we aimed to determine the predictive value of mutations in Asp299Gly and Thr399Ile of the Toll-like receptor 4 gene, and the intron 2 microsatellite polymorphism of the Toll-like receptor 2 gene on the occurrence of acute biliary pancreatitis.