Overexpression of miR-145-5p Inhibits Proliferation of Prostate Cancer Cells and Reduces SOX2 Expression


OZEN M., KARATAS O. F. , Gulluoglu S., Bayrak O. F. , Sevli S., GUZEL E., et al.

CANCER INVESTIGATION, cilt.33, ss.251-258, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 33 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/07357907.2015.1025407
  • Dergi Adı: CANCER INVESTIGATION
  • Sayfa Sayısı: ss.251-258

Özet

We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145-5p-overexpressed PCa cells. We proposed that miR-145-5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.