Endothelial constitutive nitric oxide synthase, angiotensin converting enzyme, angiotensin II type 1 receptor gene polymorphisms and endothelial functions in healthy individuals

Akpinar, T.; Ozkok, A.; Kose, M.; Atas, R.; Sumnu, A.; Bakkaloglu, O.; Erk, O.; Kayacan, M.; Oflaz, H.; Akkaya, V.; Demirel, A.

Endothelial constitutive nitric oxide synthase, angiotensin converting enzyme, angiotensin II type 1 receptor gene polymorphisms and endothelial functions in healthy individuals

Atıf İçin Kopyala

Akpinar T. S. , Ozkok A., Kose M., Atas R., Sumnu A., Bakkaloglu O. K. , ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, ss.39-45, 2014 (SCI İndekslerine Giren Dergi)

Cilt numarası: 18 Konu: 1
Basım Tarihi: 2014
Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Sayfa Sayıları: ss.39-45

Özet

INTRODUCTION: Endothelial dysfunction is recognized as an early and initiating event in the pathogenesis of coronary artery disease. Gene polymorphisms of endothelial constitutive nitric oxide synthase (ecNOS), angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor (AT1R) have been found to be associated with atherosclerosis. We aimed to investigate the possible effects of ecNOS, ACE and AT1R gene polymorphisms on endothelial functions in healthy population.