Therapeutic apheresis for severe hypertriglyceridemia in pregnancy


Basar R., Uzum A. K. , Canbaz B. , Dogansen S. C. , Kalayoglu-Besisik S., Altay-Dadin S., ...More

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.287, no.5, pp.839-843, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 287 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1007/s00404-013-2786-z
  • Title of Journal : ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Page Numbers: pp.839-843

Abstract

During pregnancy, a progressive increase in serum triglyceride (TG) and cholesterol levels is observed whereas TG levels mostly remain < 300 mg/dl. In women with genetic forms of hypertriglyceridemia, pregnancy may cause extremely elevated TG levels leading to potentially life-threatening pancreatitis attacks and chylomicronemia syndrome. The only safe medical treatment option during pregnancy is omega-3 fatty acids, which have moderate TG lowering effects. Therapeutic apheresis could be used as primary treatment approach during pregnancy.