Warfarin-Induced Skin Necrosis Due to Protein C Deficiency in a Dialysis Patient


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Ozkok A., Ozportakal H., Asik M., Ozkok S., Alkan O., Boyraz M., et al.

TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, cilt.27, ss.214-217, 2018 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 27 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5262/tndt.2018.2775
  • Dergi Adı: TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
  • Sayfa Sayısı: ss.214-217

Özet

Protein-C (PC) is a vitamin-K-dependent anticoagulant proenzyme produced by the liver. PC deficiency may cause both venous and arterial thromboses. In patients with PC deficiency, warfarin further decreases PC activity and causes thrombosis of skin arterioles leading to skin necrosis.