Warfarin-Induced Skin Necrosis Due to Protein C Deficiency in a Dialysis Patient


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Ozkok A., Ozportakal H., Asik M., Ozkok S., Alkan O., Boyraz M., ...More

TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, vol.27, no.2, pp.214-217, 2018 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5262/tndt.2018.2775
  • Title of Journal : TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
  • Page Numbers: pp.214-217

Abstract

Protein-C (PC) is a vitamin-K-dependent anticoagulant proenzyme produced by the liver. PC deficiency may cause both venous and arterial thromboses. In patients with PC deficiency, warfarin further decreases PC activity and causes thrombosis of skin arterioles leading to skin necrosis.