Immunity of Central and Peripheral Nervous System

Tavsanli M. E. , ESEN F. , Ozpinar E., Yanik E. R. , ALTINTAŞ A. T.

TURKISH JOURNAL OF IMMUNOLOGY, vol.15, no.1, pp.1-6, 2010 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2010
  • Page Numbers: pp.1-6
  • Keywords: Immunity, central nervous system, peripheral nervous system, immunological models


Immune privilege is an absent or limited response of the immune system to antigenic challenge. It seems to be of particular benefit in three organs: the brain, eye and pregnant uterus. Recent data have revealed that the CNS and PNS are not isolated from the immune system. They are in interaction with the peripheral immune system. It is more appropriate to consider the CNS and PNS to be "immune-specialized area". In this paper we aimed to review the immunity of both central and peripheral nervous system. We will also mention about specific disorders that have been understood more clearly in immune respect and experimental models of immune-mediated neurological diseases.