Evaluation of biopathogenesis of meningioma cases in the light of literature


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Gürbüz M. S. , Karaarslan N., Şimşek A. T. , Erşahin M. , Berkman M. Z.

Medeniyet Medical Journal, vol.33, no.2, pp.112-118, 2018 (International Refereed University Journal)

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5222/mmj.2018.77905
  • Title of Journal : Medeniyet Medical Journal
  • Page Numbers: pp.112-118

Abstract

In this study, it was aimed to investigate the bio pathogenesis of

the cases diagnosed with meningioma in the light of the literatu- re. The patients (n=79) operated 

due to the meningioma in neu- rosurgery department between 2005 and 2010 were retrospec- tively 

examined. Findings that may affect the biological behavior and  prognosis  of  the  tumours  

recorded  in  these  reported  data were evaluated. A total of 79 cases meeting the research 

criteria were included in the study. When the histopathological grade of the cases was examined, it 

was seen that 59 cases (74.7%) were grade I and 20 cases (25.3%) were grade II. When the relation 

between the localization and histological grade of the cases was examined, it was determined that 

the meningiomas were most frequently located in convexity and that most of grade II cases were 

localized at this site. Preoperative peritumoral oedema was found to be more prevalent, especially 

in the sphenoid wing and convexity meningiomas. A total of 9 cases of recurrence (11.4%) occurred  

during  follow-up  period.  When  carrying  out  evaluati- on between surgical resection grade and 

recurrent cases, it was detected that all cases where it was performed Simpson grade IV and 

Kobayashi grade IVA and IVB resection had a recurrence. When the localization of recurrent cases 

was examined, it was seen  that  4  cases  (%44.4)  were  sphenoid  wing  meningioma,  2 cases  

(%22.2)  were  parasagittal  meningioma,  1  case  (%11.1) was tuberculosis sellae meningioma and 1 

case (%11.1) was int- raventricular meningioma. In our study, histopathologic subtype and  surgical 

 resection  grade  were  found  to  play  a  significant role in prognosis in meningiomas. It was 

also thought that the presence of peritumoral oedema and tumour localization could affect the 

biological behavior and prognosis of the meningioma. Findings  obtained  should  be  supported  by  

multi-center  studies that will include the cases of different races with more series.