Oxygen radicals and nitric oxide in rat mesenteric ischaemia-reperfusion: Modulation by L-arginine and N-G-nitro-L-arginine methyl ester


Haklar G., ULUKAYA DURAKBAŞA Ç., Yüksel M., Dağlı T., Yalçın A. S.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.25, no.11, pp.908-912, 1998 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 11
  • Publication Date: 1998
  • Doi Number: 10.1111/j.1440-1681.1998.tb02342.x
  • Journal Name: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.908-912
  • Keywords: chemiluminescence, mesenteric ischaemia/reperfusion, nitric oxide, reactive oxygen species, superoxide radical, thiobarbituric acid-reactive substances, SUPEROXIDE, INJURY, PEROXYNITRITE

Abstract

1. The aims of the present study were to detect changes in superoxide anion (O-2(.-)), nitric oxide (NO) and other reactive oxygen species (ROS) directly by measurement of chemiluminescence (CL) and to investigate the role of L-arginine, a nitric oxide synthase (NOS) substrate, and N-G-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, together with their molecular enantiomers D-arginine and D-NAME, in a rat mesenteric ischaemia-reperfusion (I/R) model.