Oxygen radicals and nitric oxide in rat mesenteric ischaemia-reperfusion: Modulation by L-arginine and N-G-nitro-L-arginine methyl ester


Haklar G., ULUKAYA DURAKBAŞA Ç. , Yüksel M., Dağlı T., Yalçın A. S.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.25, ss.908-912, 1998 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 25 Konu: 11
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1111/j.1440-1681.1998.tb02342.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Sayfa Sayısı: ss.908-912

Özet

1. The aims of the present study were to detect changes in superoxide anion (O-2(.-)), nitric oxide (NO) and other reactive oxygen species (ROS) directly by measurement of chemiluminescence (CL) and to investigate the role of L-arginine, a nitric oxide synthase (NOS) substrate, and N-G-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, together with their molecular enantiomers D-arginine and D-NAME, in a rat mesenteric ischaemia-reperfusion (I/R) model.