This study aims to measure the effects of empowerment and learned resourcefulness on work-related stress in organizations. The sample of the study is composed of 125 employees working in public sector in Eskişehir. Within the scope of the study related scales utilized to measure the level of learned resourcefulness, empowerment, and stress-related pressure of the participants. With that, the required correlation and regression analyses were performed. The results of the analysis indicated a significant relationship exists between the “help-seeking” subscale of the learned resourcefulness. Also, the result of the correlation analysis revealed a significant relationship exists between work-related stress and “autonomy” dimension of the empowerment variable. This result emphasizes the importance of employees' perceptions of taking the initiative in order to manage work-related stress /pressure sources effectively. However, the “help-seeking” related behaviors from others resulted in negatively correlated relation with the organizational stressors. The research reveals the relationship between the learned strengths and work stress of employees working for a public institution in Eskişehir.