The Neurochemical Effects of Prazosin Treatment on Fear Circuitry in a Rat Traumatic Stress Model


Ketenci S., ACET N. G. , Saridogan G. E. , AYDIN OMAY B., CABADAK H., GÖREN M. Z.

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, vol.18, no.2, pp.219-230, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.9758/cpn.2020.18.2.219
  • Title of Journal : CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Page Numbers: pp.219-230

Abstract

Objective: The timing of administration of pharmacologic agents is crucial in traumatic stress since they can either potentiate the original fear memory or may cause fear extinction depending on the phase of fear conditioning. Brain noradrenergic system has a role in fear conditioning. Data regarding the role of prazosin in traumatic stress are controversial.