The effects of 3-benzoyl-1-methyl-4-phenyl-4-piperidinolhydrochloride (C1), indomethacin, nimesulide and rofecoxib on cyclooxygenase activities in carrageenan-induced paw edema model


Sahin y., DEMİRCAN B. , Suleyman H., Aksoy H., Gul H.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.40, ss.723-728, 2010 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 40 Konu: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3906/sag-0908-187
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayısı: ss.723-728

Özet

Aim: The aim of this study was to investigate the effects of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol-hydrochloride (C1) which is a structural and also non-classical isomer of bis Mannich base, bis (3-aryl-3-oxo-propyl) methylamine hydrochlorides (B1), on cyclooxygenase (COX) activities in 48 rats with inflammation by using carrageenan-induced paw edema, and to compare its effect with other non-steroidal anti-inflammatory drugs (NSAIDs).