Influence of conversion from calcineurin inhibitors to everolimus on fibrosis, inflammation, tubular damage and vascular function in renal transplant patients


Alpay N., Ozkok A., Caliskan Y., Akagun T., Cinar S. A. , Deniz G., ...More

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.18, no.6, pp.961-967, 2014 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1007/s10157-014-0939-4
  • Title of Journal : CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Page Numbers: pp.961-967

Abstract

Conversion from calcineurin inhibitor (CNI) to mTOR inhibitors may reduce and even halt the progression of chronic allograft dysfunction (CAD) which is the most important cause of renal allograft loss. We aimed to investigate the effects of conversion from CNI to everolimus on parameters of fibrosis, inflammation, glomerulotubular damage and vascular functions in renal transplant recipients.