Is the presence of AA amyloidosis associated with impaired coronary flow reserve?


Bulut M., Keleş N., Caliskan Z., Kostek O., Aksu F., Akçakoyun M., ...More

ATHEROSCLEROSIS, vol.251, pp.389-395, 2016 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 251
  • Publication Date: 2016
  • Doi Number: 10.1016/j.atherosclerosis.2016.05.041
  • Journal Name: ATHEROSCLEROSIS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.389-395

Abstract

Background and aims: Systemic amyloid A protein (AA) amyloidosis may occur as a complication of many chronic inflammatory disorders. Patients receiving inadequate anti-inflammatory and immunosuppressive therapies have an increased risk of developing systemic AA amyloidosis. Inflammation plays a role in all stages and the thrombotic complications of atherosclerosis. In the absence of epicardial coronary stenosis, coronary flow reserve (CFR) reflects coronary microvascular dysfunction. In the present study, we hypothesized that amyloid advanced subclinical inflammation in chronic inflammatory diseases (CID) patients may further affect coronary microcirculation.