Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women

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Warren J. L. , Bulur Ş., Ovalle F., Windham S. T. , Gower B. A. , Fisher G.

METABOLISM-CLINICAL AND EXPERIMENTAL, vol.77, pp.1-12, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77
  • Publication Date: 2017
  • Doi Number: 10.1016/j.metabol.2017.08.004
  • Journal Name: METABOLISM-CLINICAL AND EXPERIMENTAL
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1-12
  • Keywords: Hyperinsulinemia, Respirometry, Mitochondrial plasticity, Mitochondrial uncoupling, TYPE-2 DIABETES-MELLITUS, INSULIN-RESISTANCE, OXIDATIVE STRESS, UNCOUPLING PROTEINS, ENERGY TRANSDUCTION, MODEL ASSESSMENT, GENE-EXPRESSION, EXERCISE, OBESITY, MORPHOLOGY

Abstract

Background. Acute metabolic demands that promote excessive and/or prolonged reactive oxygen species production may stimulate changes in mitochondrial oxidative capacity.