Identification of potential allosteric communication pathways between functional sites of the bacterial ribosome by graph and elastic network models


Guzel P. , Kurkcuoglu O.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol.1861, no.12, pp.3131-3141, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 1861 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1016/j.bbagen.2017.09.005
  • Title of Journal : BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Page Numbers: pp.3131-3141

Abstract

Background: Accumulated evidence indicates that bacterial ribosome employs allostery throughout its structure for protein synthesis. The nature of the allosteric communication between remote functional sites remains unclear, but the contact topology and dynamics of residues may play role in transmission of a perturbation to distant sites.