Identification of potential allosteric communication pathways between functional sites of the bacterial ribosome by graph and elastic network models


Guzel P. , Kurkcuoglu O.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1861, ss.3131-3141, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 1861 Konu: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.bbagen.2017.09.005
  • Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Sayfa Sayısı: ss.3131-3141

Özet

Background: Accumulated evidence indicates that bacterial ribosome employs allostery throughout its structure for protein synthesis. The nature of the allosteric communication between remote functional sites remains unclear, but the contact topology and dynamics of residues may play role in transmission of a perturbation to distant sites.