Capecitabine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy


Bora E. S. , Tastaynatan H., ERDOĞAN M. A. , Atasoy O., Erbas O.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, vol.12, pp.166-170, 2021 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2021
  • Doi Number: 10.4328/acam.20407
  • Journal Name: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Journal Indexes: Emerging Sources Citation Index
  • Page Numbers: pp.166-170
  • Keywords: Capecitabine, Cancer therapy, Epilepsy, Folat level, Brain, FOLIC-ACID, ANTIEPILEPTIC DRUGS, CONTINUOUS SPIKES, SERUM FOLATE, ANTICONVULSANTS, WAVES

Abstract

Aim: Capecitabine was developed as a pro-drug of 5-FU. Epilepsy is a common and often debilitating neurological disease that is characterized by recurrent spontaneous seizures arising from abnormal electrical activity in the brain. The mechanism of the excitatory properties of folates is uncertain, but there is some evidence that they may act by blocking or reversing GABA-mediated inhibition.