Recent and ongoing literature strongly implies the existence of a significant and robust impact of trade openness (liberalisation) and globalisation on unemployment, particularly in developed economies. This paper empirically investigates the impacts of four different measures of trade openness and globalisation on the unemployment rate in an unbalanced panel framework. The analysis focuses on the G7 countries: Canada, France, Germany, Italy, Japan, the United Kingdom (UK), and the United States (US). Robust empirical findings from panel data estimates demonstrate that, along with macroeconomic indicators and market size, all the measures of trade openness and globalisation are significantly and negatively associated with the unemployment rate. Therefore, we conclude that the continuation of the globalisation process instead of protectionism is of great importance in reducing the unemployment rate in developed economies.