Annals of diagnostic pathology, cilt.44, ss.151431, 2019 (SCI İndekslerine Giren Dergi)
Background: The pre-biopsy (bx) prostate-specific antigen (PSA) level, tumor volume/diameter, degree of ex- traprostatic extension (EPE), and extent of surgical margin positivity have been shown to be significant prog- nostic parameters of biochemical recurrence (BCR) after radical prostatectomy. The present study assessed the cut-off values of the pre-bx PSA level, maximum tumor diameter, radial and circumferential distances of EPE, and circumferential length of surgical margin (SM) positivity with regard to BCR.
Material and methods: The study included 445 radical prostatectomy specimens, and the cut-off values of all parameters were determined using receiver operating characteristic curve analysis.
Results: An ISUP grade group ≥ 3, radial distance of EPE > 1 mm, and circumferential length of SM positivity ≥2 mm were identified as independent predictors of BCR after radical prostatectomy. The parameters that showed statistical significance in univariate analysis, such as pre-bx PSA level≥7.20ng/mL, tumor dia- meter ≥ 19.5 mm, presence of seminal vesicle invasion, and circumferential distance of EPE > 3 mm, did not have independent prognostic values for BCR.
Conclusions: An ISUP grade group ≥ 3, radial distance of EPE > 1 mm, and circumferential length of SM posi- tivity ≥2 mm are predictors of BCR. Our findings might have significance in risk classification and adjuvant therapy consideration among patients with localized prostate cancer.