Determining the cut-off values of tumor diameter, degree of extraprostatic extension, and extent of surgical margin positivity with regard to biochemical recurrence of prostate cancer after radical prostatectomy.


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Kir G., Arikan E., Seneldir H. , Ankarali H. , Oznergiz S., Olgun Z., et al.

Annals of diagnostic pathology, cilt.44, ss.151431, 2019 (SCI İndekslerine Giren Dergi)

Özet

Background: The pre-biopsy (bx) prostate-specific antigen (PSA) level, tumor volume/diameter, degree of ex- traprostatic extension (EPE), and extent of surgical margin positivity have been shown to be significant prog- nostic parameters of biochemical recurrence (BCR) after radical prostatectomy. The present study assessed the cut-off values of the pre-bx PSA level, maximum tumor diameter, radial and circumferential distances of EPE, and circumferential length of surgical margin (SM) positivity with regard to BCR.

Material and methods: The study included 445 radical prostatectomy specimens, and the cut-off values of all parameters were determined using receiver operating characteristic curve analysis.
Results: An ISUP grade group ≥ 3, radial distance of EPE > 1 mm, and circumferential length of SM positivity 2 mm were identified as independent predictors of BCR after radical prostatectomy. The parameters that showed statistical significance in univariate analysis, such as pre-bx PSA level7.20ng/mL, tumor dia- meter ≥ 19.5 mm, presence of seminal vesicle invasion, and circumferential distance of EPE > 3 mm, did not have independent prognostic values for BCR.

Conclusions: An ISUP grade group ≥ 3, radial distance of EPE > 1 mm, and circumferential length of SM posi- tivity 2 mm are predictors of BCR. Our findings might have significance in risk classification and adjuvant therapy consideration among patients with localized prostate cancer.