Effects of JAM-A rs790056 and LFA-1 rs8058823 Variations on Kidney Cancer

Pence H. H. , Caykara B., Pence S., Tokat B., Otunctemur A.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, vol.9, 2019 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2019
  • Doi Number: 10.5152/jarem.2019.2891
  • Journal Name: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
  • Journal Indexes: Emerging Sources Citation Index, TR DİZİN (ULAKBİM)

Abstract

Objective: Kidney cancer is a type of cancer that includes different histology subgroups, and the number of kidney cancer cases is expected to increase. It has been found that the junctional adhesion molecule A (JAM-A) as a transmembrane glycoprotein is associated with cancer characteristics such as invasion, metastasis, and poor prognosis. Therefore, we aimed to investigate the effect of gene variations in JAM-A and its ligand lymphocyte function-related antigen-1 (LFA-1) on kidney cancer.