99mTc-labeled Red Blood Cell SPECT for Diagnosis and Follow up of Juvenile Nasopharyngeal Angiofibroma.

Uslu C., Yildirim M., USLU SINAV H. , Sütbeyaz y., Varoglu E., Seven B., ...More

Nuc Med.Comm., no.27, pp.489-494, 2006 (Journal Indexed in SCI)

  • Publication Type: Article / Article
  • Publication Date: 2006
  • Title of Journal : Nuc Med.Comm.
  • Page Numbers: pp.489-494


Aim: To confirm the usefulness of blood pool scintigraphy with 99mTc-labelled red blood cells (99mTc-RBCs) in the diagnosis and follow-up of juvenile nasopharyngeal angiofibroma. Methods: A prospective study design was used. 99mTc-RBCs were prepared by a modified in-vivo method. After the rapid intravenous injection of 370-740 MBq of 99mTc-RBCs, dynamic imaging of 1-min duration was performed. After dynamic imaging, static acquisitions at 5 min (second phase: blood pool phase) and 2 h (third phase: static image) were obtained. In addition, single-photon emission computed tomography (SPECT) imaging was performed at 2 h. SPECT images were obtained using a rotating gamma camera (GE-Starcam 4000 XR/T). Results: All patients showed no activity in the first phase and mild activity in the second phase (blood pool phase). All patients with juvenile nasopharyngeal angiofibroma showed a prominent increased activity in the third phase and in SPECT images. Conclusions: This study shows that blood pool scintigraphy with 99mTc-RBC SPECT is very accurate, easy to perform and a suitable alternative to pre-operative and post-operative imaging techniques, including computed tomography scan, magnetic resonance imaging (MRI) and MRI angiography, for the detection of juvenile nasopharyngeal angiofibroma.