JOURNAL OF GASTROINTESTINAL SURGERY, vol.13, no.9, pp.1707-1716, 2009 (Peer-Reviewed Journal)
Article / Article
JOURNAL OF GASTROINTESTINAL SURGERY
Science Citation Index Expanded, Scopus
Simvastatin, Wound healing, Anatomosis, Dehiscence, Bursting pressure, Hydroxyproline, SMOOTH-MUSCLE-CELLS, COLORECTAL-CANCER, COLONIC ANASTOMOSES, CURATIVE RESECTION, STATINS, RISK, REPERFUSION, SECRETION, SURVIVAL, LEAKAGE
Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis.