Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat


Cakmak G. K. , Irkorucu O., Ucan B. H. , Emre A. U. , Bahadir B., Demirtas C., et al.

JOURNAL OF GASTROINTESTINAL SURGERY, cilt.13, ss.1707-1716, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 13 Konu: 9
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s11605-009-0951-2
  • Dergi Adı: JOURNAL OF GASTROINTESTINAL SURGERY
  • Sayfa Sayısı: ss.1707-1716

Özet

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis.