Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat


Cakmak G. K. , Irkorucu O., Ucan B. H. , Emre A. U. , Bahadir B., Demirtas C., ...More

JOURNAL OF GASTROINTESTINAL SURGERY, vol.13, no.9, pp.1707-1716, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1007/s11605-009-0951-2
  • Title of Journal : JOURNAL OF GASTROINTESTINAL SURGERY
  • Page Numbers: pp.1707-1716

Abstract

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis.