Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat


Cakmak G. K. , Irkorucu O., Ucan B. H. , Emre A. U. , Bahadir B., Demirtas C., ...More

JOURNAL OF GASTROINTESTINAL SURGERY, vol.13, no.9, pp.1707-1716, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1007/s11605-009-0951-2
  • Journal Name: JOURNAL OF GASTROINTESTINAL SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1707-1716
  • Keywords: Simvastatin, Wound healing, Anatomosis, Dehiscence, Bursting pressure, Hydroxyproline, SMOOTH-MUSCLE-CELLS, COLORECTAL-CANCER, COLONIC ANASTOMOSES, CURATIVE RESECTION, STATINS, RISK, REPERFUSION, SECRETION, SURVIVAL, LEAKAGE

Abstract

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis.