Serum gamma-glutamyltransferase levels are inversely related to endothelial function in chronic kidney disease

Yilmaz I., Turgut F., KANBAY M. , Saglam M., Sonmez A., Yaman H., et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.45, ss.1071-1078, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 45 Konu: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s11255-012-0354-2
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Sayfa Sayısı: ss.1071-1078

Özet

Gamma-glutamyltransferase (GGT) is an enzyme responsible for the extracellular catabolism of the antioxidant glutathione and recently implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is a prodromal feature of atherogenesis. Since oxidative stress is highly present in uremia and causally linked to endothelial dysfunction, we hypothesized that GGT may be a factor implicated in this process.