Serum gamma-glutamyltransferase levels are inversely related to endothelial function in chronic kidney disease

Yilmaz, Ilker; Turgut, Faruk; KANBAY, MEHMET; Saglam, Mutlu; Sonmez, Alper; Yaman, Halil; Demirbas, Senol; Unal, Hilmi; Gok, Mahmut; Karaman, Murat; Ay, Sadik; Demirkaya, Erkan; Covic, Adrian; Carrero, Juan

doi:10.1007/s11255-012-0354-2

Serum gamma-glutamyltransferase levels are inversely related to endothelial function in chronic kidney disease

Yilmaz I., Turgut F., KANBAY M. , Saglam M., Sonmez A., Yaman H., ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.45, no.4, pp.1071-1078, 2013 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 45 Issue: 4
Publication Date: 2013
Doi Number: 10.1007/s11255-012-0354-2
Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
Page Numbers: pp.1071-1078

Abstract

Gamma-glutamyltransferase (GGT) is an enzyme responsible for the extracellular catabolism of the antioxidant glutathione and recently implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is a prodromal feature of atherogenesis. Since oxidative stress is highly present in uremia and causally linked to endothelial dysfunction, we hypothesized that GGT may be a factor implicated in this process.