Serum gamma-glutamyltransferase levels are inversely related to endothelial function in chronic kidney disease


Yilmaz I., Turgut F., KANBAY M. , Saglam M., Sonmez A., Yaman H., ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.45, no.4, pp.1071-1078, 2013 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.1007/s11255-012-0354-2
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.1071-1078

Abstract

Gamma-glutamyltransferase (GGT) is an enzyme responsible for the extracellular catabolism of the antioxidant glutathione and recently implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is a prodromal feature of atherogenesis. Since oxidative stress is highly present in uremia and causally linked to endothelial dysfunction, we hypothesized that GGT may be a factor implicated in this process.