Serum gamma-glutamyltransferase levels are inversely related to endothelial function in chronic kidney disease

Yilmaz, Ilker; Turgut, Faruk; KANBAY, MEHMET; Saglam, Mutlu; Sonmez, Alper; Yaman, Halil; Demirbas, Senol; Unal, Hilmi; Gok, Mahmut; Karaman, Murat; Ay, Sadik; Demirkaya, Erkan; Covic, Adrian; Carrero, Juan

doi:10.1007/s11255-012-0354-2

Serum gamma-glutamyltransferase levels are inversely related to endothelial function in chronic kidney disease

Atıf İçin Kopyala

Yilmaz I., Turgut F., KANBAY M. , Saglam M., Sonmez A., Yaman H., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.45, ss.1071-1078, 2013 (SCI İndekslerine Giren Dergi)

Cilt numarası: 45 Konu: 4
Basım Tarihi: 2013
Doi Numarası: 10.1007/s11255-012-0354-2
Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
Sayfa Sayıları: ss.1071-1078

Özet

Gamma-glutamyltransferase (GGT) is an enzyme responsible for the extracellular catabolism of the antioxidant glutathione and recently implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is a prodromal feature of atherogenesis. Since oxidative stress is highly present in uremia and causally linked to endothelial dysfunction, we hypothesized that GGT may be a factor implicated in this process.